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Pantopon, also known as Opium Alkaloids Hydrochlorides, is a preparation of opiates made up of all of the alkaloids present in opium in their natural proportions as hydrochlorides salts. [1] [2] [3] It can sometimes be tolerated by people who are allergic to morphine.
An opiate is an alkaloid substance derived from opium (or poppy straw). [1] It differs from the similar term opioid in that the latter is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain (including antagonists). [2]
Some minor opium alkaloids and various substances with opioid action are also found elsewhere, including molecules present in kratom, Corydalis, and Salvia divinorum plants and some species of poppy aside from Papaver somniferum. There are also strains which produce copious amounts of thebaine, an important raw material for making many semi ...
Opium poppy contains at least 50 different alkaloids, but most of them are of very low concentration. Morphine is the principal alkaloid in raw opium and constitutes roughly 8–19% of opium by dry weight (depending on growing conditions). [84] Some purpose-developed strains of poppy now produce opium that is up to 26% morphine by weight.
Opiates are alkaloid compounds naturally found in the Papaver somniferum plant (opium poppy). The psychoactive compounds found in the opium plant include morphine, codeine, and thebaine. Opiates have long been used for a variety of medical conditions with evidence of opiate trade and use for pain relief as early as the eighth century AD.
Traditionally, opium is harvested while the seed pods are green and the seeds have just begun to grow and their latex is abundant. Poppy straw can be a by-product of cultivation of poppy seeds. Compared to the seed pod and straw, the seeds contain very low levels of opiates . [ 7 ]
This alkaloid is biosynthetically related to salutaridine, oripavine, morphine and reticuline. [6] In 2012 there was an amounted 146,000 kilograms of thebaine produced. [7] In 2013, Australia was the main producer of poppy straw rich in thebaine, followed by Spain and then France. By 2017, worldwide thebaine production dropped to 2,008 kg. [8]
The first individual alkaloid, morphine, was isolated in 1804 from the opium poppy (Papaver somniferum). [1] Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral [2] and even weakly acidic properties. [3]