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DU145, PC3, and LNCaP are considered to be the standard prostate cancer cell lines used in therapeutic research. [ 1 ] The DU145 cell line was derived from a central nervous system metastasis , of primary prostate adenocarcinoma origin, removed during a parieto-occipital craniotomy of a 69-year-old, White, male.
Eventually cancer cells can grow resistant to this treatment. This most-advanced stage of the disease, called castration-resistant prostate cancer, is treated with continued hormone therapy alongside the chemotherapy drug docetaxel. Some tumors metastasize (spread) to other areas of the body, particularly the bones and lymph nodes.
Other names for this stage are metastatic castrate-resistant (mCRPC) and androgen independent (AI) or (AIPC). This stage leads to mCRPC with lymph node involvement and distal (distant) tumors; this is the lethal stage of CaP. The prostate cancer staging designation is T4,N1,M1c. [5] [6] [7]
Irreversible electroporation (IRE) is an emerging focal therapy for prostate cancer, particularly suitable for small tumors confined to the prostate. Unlike traditional treatments such as radical prostatectomy or radiation therapy, which may lead to side effects like urinary incontinence and erectile dysfunction, IRE aims to minimize such risks ...
PROSTVAC is being developed in partnership with the National Cancer Institute under a formal Cooperative Research and Development Agreement and has been the subject of multiple ongoing and completed clinical studies, including the global Phase 3 PROSPECT study underway in patients with asymptomatic or minimally symptomatic metastatic prostate cancer (mCRPC). [2]
PC3 cells have been utilized to research aggressive and castration-resistant forms of pancreatic cancer. The androgen-independence of these cells during cell division makes them invaluable for studying the molecular mechanisms embedded in studying advanced prostate cancer. [13] PC3 cells have been involved in research regarding the prevention ...
Cancer Stem Cell phenotypes are associated with disease recurrence, metastasis, and cell survival in circulation as Circulating tumor cells. Thus, activation of these programs via inhibition of the androgen axis provides a mechanism by which tumor cells can adapt to promote disease recurrence and progression. [11]
Opevesostat is an investigational new drug being developed for the treatment of metastatic castration-resistant prostate cancer (mCRPC). [1] It is a non-steroidal, selective inhibitor of CYP11A1 (cholesterol side-chain cleavage enzyme) [2] discovered by Orion Corporation and currently undergoing clinical development by Merck & Co., Inc. Opevesostat's mechanism of action involves suppressing ...
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