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Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Lixivaptan (VPA-985) is an orally-active, non-peptide, selective vasopressin 2 receptor antagonist being developed as an investigational drug by Palladio Biosciences, Inc. (Palladio), a subsidiary of Centessa Pharmaceuticals plc.
In addition to spring, ecological reckoning identifies an earlier separate prevernal (early or pre-spring) season between the hibernal (winter) and vernal (spring) seasons. This is a time when only the hardiest flowers like the crocus are in bloom, sometimes while there is still some snowcover on the ground.
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The following table gives formula for the spring that is equivalent to a system of two springs, in series or in parallel, whose spring constants are and . [1] The compliance c {\displaystyle c} of a spring is the reciprocal 1 / k {\displaystyle 1/k} of its spring constant.)
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The slight differences between the solstices and the equinoxes cause seasonal shifts along a rainy low-pressure belt called the Intertropical Convergence Zone (ICZ). As a result, the amount of precipitation tends to vary more dramatically than the average temperature. When the ICZ is north of the Equator, the northern tropics experience their ...
The forcing of the spring to the surface can be the result of a confined aquifer in which the recharge area of the spring water table rests at a higher elevation than that of the outlet. Spring water forced to the surface by elevated sources are artesian wells. This is possible even if the outlet is in the form of a 300-foot-deep (91 m) cave.