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IgA vasculitis (HSP), previously known as Henoch–Schönlein purpura, is a disease of the skin, mucous membranes, and sometimes other organs that most commonly affects children. In the skin, the disease causes palpable purpura (small, raised areas of bleeding underneath the skin), often with joint pain and abdominal pain .
Cryofibrinogenemia refers to a condition classified as a fibrinogen disorder in which a person's blood plasma is allowed to cool substantially (i.e. from its normal temperature of 37 °C to the near-freezing temperature of 4 °C), causing the (reversible) precipitation of a complex containing fibrinogen, fibrin, fibronectin, and, occasionally, small amounts of fibrin split products, albumin ...
Some typical places is the skin blood vessels around the buttocks and legs, which leads to significant skin discolouration that looks like blood is pooling under the skin surface - called purpura. One indication that the disease is Henoch-Schonlein is that the skin discoloration is palpable, as in you can feel it raise above the normal skin.
In cases where a cause can be determined, medications and infectious pathogens are most common in adults, while IgA vasculitis (Henoch–Schönlein purpura) frequently affects children. [6] Other etiologies include autoimmune conditions and malignancies, usually hematologic (related to the blood). [5] [6]
Henoch-Schonlein purpura (small blood vessel inflammation) Priapism commonly occurs in men with sickle cell disease, and the risk increases with age.
Henoch-Schönlein purpura [1] Acute hemorrhagic edema of infancy ( AHEI ) is a type of leukocytoclastic vasculitis that is not fatal. Although it causes fever, large palpable purpuric skin lesions, and edema , it is a harmless condition.
287 Purpura and other hemorrhagic conditions. 287.0 Allergic purpura Henoch–Schönlein purpura; 287.3 Thrombocytopenia, primary 287.31 Immune thrombocytopenic purpura. Idiopathic thrombocytopenic purpura; 287.4 Thrombocytopenia, secondary; 287.9 Hemorrhagic conditions, unspec.
Immune complex glomerulonephritis, as seen in Henoch-Schönlein purpura; this is an example of IgA involvement in a nephropathy. The reaction can take hours, days, or even weeks to develop, depending on whether or not there is immunological memory of the precipitating antigen. Typically, clinical features emerge a week following initial antigen ...