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Most paragangliomas are asymptomatic, present as a painless mass, or create symptoms such as hypertension, tachycardia, headache, and palpitations. [3] While all contain neurosecretory granules, only in 1–3% of cases is secretion of hormones such as catecholamines abundant enough to be clinically significant; in that case manifestations often resemble those of pheochromocytomas (intra ...
An additional benefit of the DOTA analogues is the ability for treatment with peptide receptor radionuclide therapy, which will be discussed in the treatment section below. [ 98 ] Also, HED-PET has shown to be an accurate tool to diagnose and rule out pheochromocytoma in complex clinical scenarios and to characterise equivocal adrenal tumours.
Chromaffin paragangliomas are issued from chromaffin cells, and are known as pheochromocytomas. Adrenal pheochromocytomas are usually benign while extra-adrenal ones are more malignant. [3] They are most of the time in the adrenals, and only rarely outside of the abdomen. They usually secrete hormones and estimates of a familial history vary ...
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Paragangliomas in these patients are mainly localized to the abdomen whereas somatostatinomas are found in the second portion of the duodenum, as shown by imaging or biochemistry. [1] This syndrome is of special interest as finding more than one type of neuroendocrine tumor in one individual is unusual. [ 1 ]
The therapy, branded as Ryoncil, is the first mesenchymal stromal cell therapy approved to treat pediatric patients aged two months and older whose GVHD symptoms have not responded to standard ...
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