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The esters of propionic acid have fruit-like odors and are sometimes used as solvents or artificial flavorings. [15] In biogas plants, propionic acid is a common intermediate product, which is formed by fermentation with propionic acid bacteria. Its degradation in anaerobic environments (e.g. biogas plants) requires the activity of complex ...
Propionibacterium freudenreichii was first discovered and isolated in the early 20th century by Eduard von Freudenreich and Sigurd Orla-Jensen. They discovered the bacterium while studying propionic acid fermentation in Emmental cheese.
Members of the genus Propionibacterium are widely used in the production of vitamin B 12, tetrapyrrole compounds, and propionic acid, as well as in the probiotics and cheese industries. [7] The strain Propionibacterium freudenreichii subsp. shermanii is used in cheesemaking to create CO 2 bubbles that become "eyes"—round holes in the cheese. [8]
Ibuprofen was derived from propionic acid by the research arm of Boots Group during the 1960s. [73] The name is derived from the 3 functional groups: isobutyl (ibu) propionic acid (pro) phenyl (fen). [74] Its discovery was the result of research during the 1950s and 1960s to find a safer alternative to aspirin.
Propionate fermentation is a form of fermentation with propionic acid as one of the products. This process is done through the fermentation pathway of bacteria. It is used in a variety of industrial, food-making, and medical applications.
One of the types was 2-(4-isobutylphenyl) propanoic acid; ibuprofen was first made in December 1961. Four substances that went to clinical trial failed, and the last – ibuprofen – worked; it was first called RD 13621, and RB 1472. He took the first dose himself and used the drug to treat his own headaches before it was on the market.
In 1869, Hermann Kolbe synthesised salicylic acid, although it was too acidic for the gastric mucosa. [164] The reaction used to synthesise aromatic acid from a phenol in the presence of CO 2 is known as the Kolbe-Schmitt reaction. [165] [166] [167] Kolbe–Schmitt reaction mechanism
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