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This was explored in the treatment of depression, but was shown not to be effective. Both sibutramine and venlafaxine are phenethylamine-based. At high doses, both venlafaxine and sibutramine will start producing dopaminergic effects. The inhibition of DA reuptake is unlikely to be relevant at clinically approved doses.
SSRIs are beneficial in both acute response and long-term maintenance treatment for both depression and anxiety disorder. [ 16 ] SSRIs can increase anxiety initially due to negative feedback through the serotonergic autoreceptors ; for this reason a concurrent benzodiazepine can be used until the anxiolytic effect of the SSRI occurs.
CES is used with the intention of treating a variety of conditions such as anxiety, depression and insomnia. [1] CES has been suggested as a possible treatment for headaches , fibromyalgia , smoking cessation , and opiate withdrawal, [ 1 ] but there is little evidence of effectiveness for many of these conditions and the evidence for use in ...
Transcranial direct current stimulation (tDCS) is a form of neuromodulation that uses constant, low direct current delivered via electrodes on the head. It was originally developed to help patients with brain injuries or neuropsychiatric conditions such as major depressive disorder.
With treatment-resistant depression affecting about 30% of an estimated 21 million adults with major depressive disorder, the findings are “really promising,” Badran said.
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