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This toner takes skin-brightening to the next level by pairing kojic acid with vitamin C — yet another tyrosinase inhibitor — as well as bearberry extract, a plant-based alternative to ...
Hyperpigmentation is believed to be related to the enzyme tyrosinase which produces melanin. Among several chemicals known to inhibit tyrosinase production, such as hydroquinone , arbutin , and kojic acid , 4-butylresorcinol has been found to be the most powerful inhibitor by a wide margin.
Several skin whitening agents, including tyrosinase inhibitors, have been found to cause an increase in the expression of tyrosinase, which by itself would increase melanin synthesis. [ 41 ] Microphthalmia-associated transcription factor (MITF) is the master transcription factor that controls the expression of TYR, TRP1, and TRP2, MART1 ...
Tyrosinase is an enzyme needed in melanin synthesis in the melanin producing cell of the skin, the melanocyte. By reducing the activity of tyrosinase, β-arbutin reduces the synthesis of melanin, leading to a lighter skin tone and the diminished appearance of hyperpigmentation. It is not as potent an inhibitor of tyrosinase as α-arbutin. [6]
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α-Arbutin directly inhibits the enzymatic activity of tyrosinase, which is essential for melanin synthesis. Tyrosinase catalyzes the first two steps in melanin production: the hydroxylation of tyrosine to l-DOPA and the oxidation of l-DOPA to dopaquinone. By inhibiting tyrosinase, α-arbutin reduces the formation of melanin in melanocytes. [5]
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related to: tyrosinase inhibitors for hyperpigmentation cream for sale near me opendermstore.com has been visited by 100K+ users in the past month
walmart.com has been visited by 1M+ users in the past month