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The different steps at which phages may disrupt biofilm formation. The biofilm surrounding the bacteria would inhibit the ability of antibiotics to reach bacteria, but may have less impact on the phages. Phage therapy is being used to great effect in the treatment of biofilm infections, especially Pseudomonas aeruginosa and Staphylococcus aureus.
Biofilms of fungal origin are important aspects of human infection and fungal pathogenicity, as the fungal infection is more resistant to antifungals. [161] [162] In the environment, fungal biofilms are an area of ongoing research. One key area of research is fungal biofilms on plants.
When suppressed, the biofilms are less adherent and easier to treat. The biofilm matrix of P. aeruginosa is composed of nucleic acids, amino acids, carbohydrates, and various ions. It mechanically and chemically protects P. aeruginosa from aggression by the immune system and some toxic compounds. [ 70 ]
Resistance breeding is a slow process, especially in trees. Unfortunately, P. syringae bacteria can adapt genetically to infect resistant plants, and the process for resistance breeding has to start over again. A combination treatment of bacteriophage and carvacrol shows promise in control of both the planktonic and biofilm forms. [32]
Burkholderia gladioli is a species of aerobic gram-negative rod-shaped bacteria [1] that causes disease in both humans and plants. It can also live in symbiosis with plants and fungi [2] and is found in soil, water, the rhizosphere, and in the microbiome of many animals. It was formerly known as Pseudomonas marginata.
Pseudomonas oryzihabitans, although an uncommon pathogen, is able to cause infections in individuals that usually have compromised immune systems.While most strains of this bacteria do not cause infections, the patients that acquire P. oryzihabitans most likely have an underlying disease, and it spreads while the patients are hospitalized. [5]
P. syringae is a prolific plant pathogen. It exists as over 50 different pathovars, many of which demonstrate a high degree of host-plant specificity. Numerous other Pseudomonas species can act as plant pathogens, notably all of the other members of the P. syringae subgroup, but P. syringae is the most widespread and best-studied. [citation needed]
Maggot therapy (also known as larval therapy) is a type of biotherapy involving the introduction of live, disinfected maggots (fly larvae) into non-healing skin and soft-tissue wounds of a human or other animal for the purpose of cleaning out the necrotic (dead) tissue within a wound (debridement), and disinfection. There is evidence that ...
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