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Melatonin may be useful in the treatment of delayed sleep phase syndrome. [9] Melatonin is known to reduce jet lag, especially in eastward travel. However, if it is not taken at the correct time, it can instead delay adaptation. [30] Melatonin appears to have limited use against the sleep problems of people who work shift work. [31]
When insomnia is the key issue, he typically begins with a sustained-release of 10 mg of melatonin, adding other treatments as needed. If severe daytime fatigue is present, ...
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
Then, using endogenous melatonin as a marker for circadian rhythms, several research groups showed that appropriately timed melatonin administration could entrain free-running rhythms in the totally blind: they found that 6 out of 7 patients treated with 10 mg melatonin at bedtime were normally entrained, and when the dose was gradually reduced ...
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