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The study found that the device improved outcomes, both compared to other LVAD treatments and baseline patients. Specifically, HeartMate II patients showed lower creatinine levels, 30-day survival rates were considerably higher at 96%, and 93% reached successful outcomes (transplant, cardiac recovery, or long-term LVAD). [56]
Within the study, 68 patients received an LVAD and 61 patients received optimal medical management. Among the patients who received the LVAD, there was a reduction of 48 percent in the risk of death from any cause, compared with the medical-therapy group. Rates of survival among REMATCH study patients:
According to a study by Eagle et al., patients 50–59 years old have an operative mortality rate of 1.8%, while patients older than 80 have a rate of 8.3%. [33] Other factors that increase mortality are being female, re-operation, dysfunction of the left ventricle, and left main disease . [ 33 ]
Thoratec's third-generation HeartMate LVAD is the HeartMate 3, [48] [49] designed to lower adverse event rates through improved hemocompatibility, and to increase ease of surgical placement through new design and compact size. [50] [51] It began undergoing clinical trials in the U.S. and internationally in mid 2014. [48] [49] [50] [52] [53]
A recent study found that providing immunotherapy pre- and post-surgery helps improve survival rates compared to only receiving chemotherapy before surgery.
During the late 1970s, as Hunt was completing her training, the one-year survival rates for heart transplant surgery was around 60%. Post-operative care of heart transplant patients, with long-term immunosuppression , was a new and evolving field with as yet unknown complications and problems.
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