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It can be prepared by nitration of benzoic acid. It also can be prepared by treating benzaldehyde under nitration conditions, a process that initially converts the aldehyde to the acid. 4-Nitrobenzoic acid is a precursor to 4-aminobenzoic acid, which is in turn used to prepare the anesthetic procaine. 4-Nitrobenzoic acid is prepared by ...
Also in nitration of the nitration of 3-bromobenzoic acid 5-bromo-2-nitrobenzoic acid (83%yield) was obtained as major product and 3-bromo-2-nitrobenzoic acid (13% yield) as minor. On an interesting note the potential isomer 3-bromo-4-nitrobenzoic acid was not detected.
2-Nitrobenzoic acid or o-nitrobenzoic acid is an organic compound with the formula C 6 H 4 (NO 2)CO 2 H. It is prepared by oxidation of 2-nitrotoluene with nitric acid. [1] In consists of a carboxylic acid group and a nitro group in the ortho configuration. Reduction of the nitro group into an amine produces anthranilic acid.
This reagent can be used, e.g. in the reaction with carbon dioxide to prepare benzoic acid. [4] Other methods involve palladium-catalyzed coupling reactions , such as the Suzuki reaction . Bromobenzene is used as a precursor in the manufacture of phencyclidine .
The reaction is a type of nucleophilic aromatic substitution. [4] Besides the bromo derivative, chlorine- and iodine-substituted nitroarenes, as well as more highly substituted derivatives, could also be used as substrates of this reaction. However, yields are generally poor to moderate, with reported percentage yields ranging from 1% to 50% ...
In organic chemistry, the Hammett equation describes a linear free-energy relationship relating reaction rates and equilibrium constants for many reactions involving benzoic acid derivatives with meta- and para-substituents to each other with just two parameters: a substituent constant and a reaction constant. [1] [2] This equation was ...
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Benzoic acid and its salts are used as food preservatives, represented by the E numbers E210, E211, E212, and E213. Benzoic acid inhibits the growth of mold, yeast [23] and some bacteria. It is either added directly or created from reactions with its sodium, potassium, or calcium salt. The mechanism starts with the absorption of benzoic acid ...