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CagA (cytotoxin-associated antigen A) is a major virulence factor for H. pylori, an oncoprotein that is encoded by the cagA gene. Bacterial strains with the cagA gene are associated with the ability to cause ulcers, MALT lymphomas, and gastric cancer. [108] [109] The cagA gene codes for a relatively long (1186-amino acid) protein.
The macrophages also release ROS and RNOS. Levels of 8-oxo-2'-deoxyguanosine (8-OHdG), one of the predominant forms of free radical-induced oxidative DNA damages, [46] are increased more than 8-fold in DNA after infection by H. pylori, especially if the H. pylori are cagA positive. [47] The increase in 8-OHdG likely increases mutation. [48]
Immunology is a monthly peer-reviewed medical journal covering all aspects of immunology. The editor-in-chief is Greg Delgoffe (University of Pittsburgh). It was established in 1958 and is published by Wiley-Blackwell. Through 2021, Immunology was an official journal of the British Society for Immunology. [citation needed]
This is a timeline of the events relating to the discovery that peptic ulcer disease and some cancers are caused by H. pylori. In 2005, Barry Marshall and Robin Warren were awarded the Nobel Prize in Physiology or Medicine for their discovery that peptic ulcer disease (PUD) was primarily caused by Helicobacter pylori , a bacterium with affinity ...
Nature Reviews Immunology is a monthly review journal covering the field of immunology. [1] The journal also publishes "Research highlight" articles, which are short summaries written by the editors that describe recent hot research papers. The editor-in-chief is Alexandra Flemming. [2]
The Annual Review of Immunology is a peer-reviewed scientific journal published by Annual Reviews. It releases an annual volume of review articles relevant to the field of immunology . It was first published in 1983 with inaugural editor William E. Paul ; Paul remained editor for the journal's first thirty years.
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Immunobiology is a peer-reviewed medical journal covering immunology, published by Elsevier. It was established in 1908 as the Zeitschrift für Immunitätsforschung and renamed Immunobiology in 1980. According to the Journal Citation Reports, the journal has a 2013 impact factor of 3.180. [1]
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