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2. Tazobactam - Wikipedia

   en.wikipedia.org/wiki/Tazobactam

   Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups. It is commonly used as its sodium salt , tazobactam sodium.

3. Piperacillin/tazobactam - Wikipedia

   en.wikipedia.org/wiki/Piperacillin/tazobactam

   Typically, this drug is not given through a rapid injection because the solution has high osmolality, which means it has a high concentration of particles; still, in emergency situations, it is possible to administer the drug through a rapid injection into a vein: despite the high osmolality, studies have shown that this method of ...

4. β-Lactam antibiotic - Wikipedia

   en.wikipedia.org/wiki/Β-Lactam_antibiotic

   The addition of tazobactam to piperacillin has enhanced its stability against a wide range of β-lactamase enzymes including some Extended-Spectrum β-lactamases. [20] Other β-lactamase inhibitors such as boronic acids are being studied in which they irreversibly bind to the active site of β-lactamases. This is a benefit over clavulanic acid ...

5. List of β-lactam antibiotics - Wikipedia

   en.wikipedia.org/wiki/List_of_β-lactam_antibiotics

   The β-lactam core structures. (A) A penam.(B) A carbapenam.(C) An oxapenam.(D) A penem.(E) A carbapenem.(F) A monobactam.(G) A cephem.(H) A carbacephem.(I) An oxacephem. This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class.

6. β-Lactamase inhibitor - Wikipedia

   en.wikipedia.org/wiki/Β-Lactamase_inhibitor

   Currently available beta-lactamase inhibitors are effective against Ambler Class A beta-lactamases (tazobactam, clavulanate, and sulbactam) or against Ambler Class A, C and some Class D beta-lactamases (avibactam). Like beta-lactam antibiotics, they are processed by beta-lactamases to form an initial covalent intermediate.

7. Carbapenem - Wikipedia

   en.wikipedia.org/wiki/Carbapenem

   Similar to penicillins and cephalosporins, carbapenems are members of the beta-lactam antibiotics drug class, which kill bacteria by binding to penicillin-binding proteins, thus inhibiting bacterial cell wall synthesis. However, these agents individually exhibit a broader spectrum of activity compared to most cephalosporins and penicillins.

8. Piperacillin - Wikipedia

   en.wikipedia.org/wiki/Piperacillin

   This combination is among the most widely used drug therapies in United States non-federal hospitals, accounting for $388M in spending in spite of being a low-cost generic drug. [6] Piperacillin-tazobactam is recommended as part of a three-drug regimen for the treatment of hospital-acquired pneumonia suspected as being due to infection by multi ...

9. Ceftolozane/tazobactam - Wikipedia

   en.wikipedia.org/wiki/Ceftolozane/tazobactam

   [18] [19] Tazobactam is partially metabolized to an inactive metabolite, and both drug and metabolite are excreted in the urine (80% as unchanged drug). [20] The half-life of ceftolozane is 2.5–3.0 hours, and the half-life of tazobactam is approximately 1.0 hour; the clearance of both drugs is directly proportional to renal function.