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Pomalidomide, sold under the brand names Pomalyst and Imnovid, [7] [8] is an anti-cancer medication used for the treatment of multiple myeloma and AIDS-related Kaposi sarcoma. [ 7 ] Pomalidomide was approved for medical use in the United States in February 2013, [ 10 ] and in the European Union in August 2013. [ 8 ]
The thalidomide molecule is a synthetic derivative of glutamic acid and consists of a glutarimide ring and a phthaloyl ring (Figure 5). [15] [16] Its IUPAC name is 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione and it has one chiral center [15] After thalidomide's selective inhibition of TNF-α had been reported, a renewed effort was put in thalidomide's clinical development.
Oral Anti-Cancer Therapy Pomalidomide Now Approved by European Commission as Treatment for Patients with Relapsed/Refractory Multiple Myeloma - a Rare Form of Blood Cancer BOUDRY, Switzerland ...
In 2019, Sunshine Holdings was the 16th largest conglomerate company in Sri Lanka with a brand value of LKR3,947 million. [5] The company reduced its investment in oil palm farming and dairy production and increased its stake in Watawala Tea Ceylon, a marketing company that brands Zesta and Watawala. 75% of Watawala Plantations' ownership was ...
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This is a list of largest publicly traded companies on Colombo Stock Exchange by market capitalisation in Sri Lanka. Only the top 50 companies are listed below. Only the top 50 companies are listed below.
Lenalidomide changes the substrate specificity of the CRL4 CRBN E3 ubiquitin ligase, a complex consisting of DNA-binding protein 1 , cullin 4a , regulator of cullins 1 (ROC1), and cereblon (CRBN). [9] Cereblon is the substrate adapter for the complex and is the primary molecular target of the drug. [9]
Airport and Aviation Services (Sri Lanka) Limited; The Associated Newspapers of Ceylon Ltd; B.C.C. Lanka Ltd; B.O.C. Bank; CTB BUS; Lynx BUS; Building Materials Corporation Ltd