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Bruce Ames himself argued against linear dose-response extrapolation from the high dose used in carcinogenesis tests in animal systems to the lower dose of chemicals normally encountered in human exposure, as the results may be false positives due to mitogenic response caused by the artificially high dose of chemicals used in such tests.
Ames made contributions to understanding the mechanisms of mutagenesis and DNA repair. He invented the Ames test, a widely used assay for easily and cheaply evaluating the mutagenicity of compounds. [3] The test revolutionized the field of toxicology and has played a crucial role in identifying numerous environmental and industrial carcinogens.
The Ames strain is a common strain isolated from a cow in Texas in 1981. ... "Based on the test results we have, ... Bruce Ivins' office at Fort Detrick, where he ...
The school's mission is to produce experimental test pilots, flight test engineers, and flight test navigators to lead and conduct test and evaluation of aerospace weapon systems. [1] The school was established on September 9, 1944, as the Flight Test Training Unit at Wright-Patterson Air Force Base (AFB) in Dayton, Ohio. [2]
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Mr Holton said: “Although the test takers from both lines carry FTB15831, one of them also has an additional genetic marker, indicating his descent from Robert Bruce, 3rd Baron of Clackmannan ...
The Bruce protocol is a standardized diagnostic test used in the evaluation of cardiac function and physical fitness, developed by American cardiologist Robert A. Bruce. [ 1 ] According to the original Bruce protocol the patient walks on an uphill treadmill in a graded exercise test with electrodes on the chest to monitor.