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Oxazolidine is a five-membered heterocycle ringwith the formula (CH 2) 3 (NH)O.The O atom and NH groups are not mutually bonded, in contrast to isoxazolidine. [ 2 ] [ 3 ] Oxazolidines (emphasis on plural) are derivatives of the parent oxazolidine owing to the presence of substituents on carbon and/or nitrogen.
In the Cornforth rearrangement of 4-acyloxazoles is a thermal rearrangement reaction with the organic acyl residue and the C5 substituent changing positions. Various oxidation reactions. One study [ 7 ] reports on the oxidation of 4,5-diphenyloxazole with 3 equivalents of CAN to the corresponding imide and benzoic acid :
[4] Nine years later Gabriel returned to the topic together with G. Eschenbach, developing a more efficient synthesis using sodium bicarbonate instead of the silver salt. They referred to the compound as "Oxäthylcarbaminsäureanhydrid" (hydroxyethylcarbamic acid anhydride), recognizing its relationship to ethanolamine and its cyclic structure.
This is a list of aminorex analogues. Aminorex itself is a stimulant drug with a 5-phenyl-2-amino-oxazoline structure. It was developed in the 1960s as an anorectic, [1] [2] [3] but withdrawn from sale after it was discovered that extended use produced pulmonary hypertension, often followed by heart failure, which resulted in a number of deaths. [4]
2-phenyl-3-methyl-4-ethylmorpholine (phenmetetrazine) 92196-09-3 2-phenyl-3,5-dimethylmorpholine : 1218345-44-8 2-phenyl-3,6-dimethylmorpholine (6-methylphenmetrazine, 3,6-DMPM) 92902-99-3 2-phenyl-5,5-dimethylmorpholine : 42013-48-9 2-phenyl-3-methylmorpholin-5-one (fenmetramide) 5588-29-4 4-isopropyl-2-phenylmorpholine [5] 23222-62-0
Isoxazolidines can be produced by the nitrone-olefin (3+2) cycloaddition reaction. They represent precursors to 1,3-aminoalcohols. [2] The series Organic Syntheses provides detailed procedures that yield isoxazolidines, e.g., from styrene [3] and N-phenylmaleimide. [4] Some isoxazolidines are of medicinal interest. [5]
Oxymetazoline, sold under the brand name Afrin among others, is a topical decongestant and vasoconstrictor medication. It is available over-the-counter as a nasal spray to treat nasal congestion and nosebleeds, as eye drops to treat eye redness due to minor irritation, and (in the United States) as a prescription topical cream to treat persistent facial redness due to rosacea in adults.
3,4-Methylenedioxyphenylpropan-2-one [1] or piperonyl methyl ketone (MDP2P or PMK) is a chemical compound consisting of a phenylacetone moiety substituted with a methylenedioxy functional group. It is commonly synthesized from either safrole (which, for comparison, is 3-[3,4-(methylenedioxy)phenyl]-2-propene) or its isomer isosafrole via ...