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Such a quadruplex is described as tetramolecular, reflecting the requirement of four separate strands. The term G4 DNA was originally reserved for these tetramolecular structures that might play a role in meiosis. [5] However, as currently used in molecular biology, the term G4 can mean G-quadruplexes of any molecularity.
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As an example, the separation step for ribonucleotide cleavage often utilizes affinity chromatography, in which a biological tag attached to each DNA strand is removed from any catalytically active strands via cleavage of a ribonucleotide base. This allows the catalytic strands to be separated by a column that specifically binds the tag, since ...
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Scientific workflow and data integration system Unix-like: Academic Free: Collaborative project GenePattern: Scientific workflow system that provides access to hundreds of genomic analysis tools Unix-like (public server); Linux, macOS, Windows: MIT: Broad Institute, UC San Diego: Geworkbench: Genomic data integration platform Linux, macOS, Windows
According to the developers, this theory gives significant improvement over G3-theory. The G4 and the related G4MP2 methods have been extended to cover transition metals. [5] A variant of G4MP2, termed G4(MP2)-6X, has been developed with an aim to improve the accuracy with essentially identical quantum chemistry components. [6]
A codon table can be used to translate a genetic code into a sequence of amino acids. [1] [2] The standard genetic code is traditionally represented as an RNA codon table, because when proteins are made in a cell by ribosomes, it is messenger RNA (mRNA) that directs protein synthesis.
Lately, enhancers have been shown to be involved in certain medical conditions, for example, myelosuppression. [11] Since 2022, scientists have used artificial intelligence to design synthetic enhancers and applied them in animal systems, first in a cell line, [ 12 ] and one year later also in vivo.