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Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Specifically, metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite ...
[1] [2] The branches of science known informally as omics are various disciplines in biology whose names end in the suffix -omics, such as genomics, proteomics, metabolomics, metagenomics, phenomics and transcriptomics. The related suffix -ome is used to address the objects of study of such fields, such as the genome, proteome or metabolome ...
Another paper in Science by Pauling in 1968, [8] introduced and defined this view of molecular medicine that focuses on natural and nutritional substances used for treatment and prevention. Published research and progress was slow until the 1970s' "biological revolution" that introduced many new techniques and commercial applications. [9]
The first book on metabolomics was published in 2003. [5] The first journal dedicated to metabolomics (titled simply "Metabolomics") was launched in 2005 and is currently edited by Prof. Roy Goodacre. Some of the more significant early papers on metabolome analysis are listed in the references below. [6] [7] [8] [9]
The International Science Olympiads are a group of worldwide annual competitions in various areas of the formal sciences, natural sciences, and social sciences.The competitions are designed for the 4-6 best high school students from each participating country selected through internal National Science Olympiads, with the exception of the IOL, which allows two teams per country, the IOI, which ...
Metabolite Set Enrichment Analysis (MSEA) is a method designed to help metabolomics researchers identify and interpret patterns of metabolite concentration changes in a biologically meaningful way. [1] It is conceptually similar to another widely used tool developed for transcriptomics called Gene Set Enrichment Analysis or GSEA. [2]
Logo of the International Biology Olympiad. The International Biology Olympiad (IBO) is a biological olympiad for pre-university students under the age 20, and is one of the most well-known International Science Olympiads. The first IBO was held in Czechoslovakia in 1990, and it has since been held annually. The competition has gradually ...
In principle, any technologies used for metabolomics can be used for exometabolomics. However, liquid chromatography–mass spectrometry (LC–MS) has been the most widely used. [ 3 ] As with typical metabolomic measurements, metabolites are identified based on accurate mass, retention time, and their MS/MS fragmentation patterns, in comparison ...