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The endocrine effects of hormonal oxytocin, and the cognitive or behavioral effects of oxytocin neuropeptides are thought to be coordinated through its common release through these collaterals. [48] Oxytocin is also produced by some neurons in the paraventricular nucleus that project to other parts of the brain and to the spinal cord. [49]
Stress is one of the strongest risk factors in the development of depression, and as breastfeeding reduces stress it may decrease the risk of postpartum depression in mothers. [3] Improved sleep patterns, improvements in mother-child bonding and an increased sense of self-efficacy due to breastfeeding also reduces the risk of developing depression.
Oxytocin's uterine-contracting properties were discovered by British pharmacologist Henry Hallett Dale in 1906. [9] Oxytocin's milk ejection property was described by Ott and Scott in 1910 [44] and by Schafer and Mackenzie in 1911. [45] Oxytocin was the first polypeptide hormone to be sequenced [46] or synthesized.
A review of 38 randomized and controlled trials suggests that short-term use of intranasal oxytocin appears to have few side-effects, with no difference when compared to a placebo group. Short-term use of intranasal oxytocin (OT) appears to be equally safe in vulnerable individuals as well as those deemed healthy. Three adverse incidents have ...
Oxytocin is released at orgasm and is associated with both sexual pleasure and the formation of emotional bonds. [13] Based on the pleasure model of sexual motivation, the increased sexual pleasure that occurs following oxytocin release may encourage motivation to engage in future sexual activities.
They control the body's response to stress [8] and infection. [9] They regulate the body's metabolism, influencing eating and drinking behaviour, and influence how energy intake is utilised, that is, how fat is metabolised. [10] They influence and regulate mood, [11] body fluid and electrolyte homeostasis, [12] and blood pressure. [13]
This leads to a restoration in HPA activity and stress reactivity, thus restoring the deleterious effects induced by stress on 5-HT. [ 125 ] The hypothalamic-pituitary-adrenal axis is a chain of endocrine structures that are activated during the body's response to stressors of various sorts.
A neurohormone is any hormone produced and released by neuroendocrine cells (also called neurosecretory cells) into the blood. [1] [2] By definition of being hormones, they are secreted into the circulation for systemic effect, but they can also have a role of neurotransmitter or other roles such as autocrine (self) or paracrine (local) messenger.