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A countercurrent mechanism system is a mechanism that expends energy to create a concentration gradient. It is found widely in nature and especially in mammalian organs. For example, it can refer to the process that is underlying the process of urine concentration, that is, the production of hyperosmotic urine by the mammalian kidney .
Initially the countercurrent exchange mechanism and its properties were proposed in 1951 by professor Werner Kuhn and two of his former students who called the mechanism found in the loop of Henle in mammalian kidneys a Countercurrent multiplier [14] and confirmed by laboratory findings in 1958 by Professor Carl W. Gottschalk. [15]
In other words, the length of the loop of Henle limits the concentration of the gradient, i.e., the longer the loop, the greater the osmotic gradient. Thus, longer loops would allow for steeper gradients and greater capacity to concentrate urine. Through the countercurrent multiplier the loop of Henle increases the osmolarity of the medulla.
In contrast, the epithelium transitions to a simple squamous type in the thin segment, which is less metabolically active and has minimal surface specializations. The presence of aquaporin-1 channels in the thin segment facilitates high water permeability, crucial for water reabsorption as part of the kidney's countercurrent exchange mechanism ...
The predominant mechanism of active transport in this segment is through the Na + /K + /Cl − co-transporter NKCC2 as well as the sodium/hydrogen exchanger NHE3. [4] In total this segment accounts for approximately 25–30% of total Na + reabsorption along the nephron.
The number of transfer units (NTU) method is used to calculate the rate of heat transfer in heat exchangers (especially parallel flow, counter current, and cross-flow exchangers) when there is insufficient information to calculate the log mean temperature difference (LMTD). Alternatively, this method is useful for determining the expected heat ...
The effect of this biological heat exchanger is that the internal temperature of the feet is much closer to the ambient temperature, thus reducing heat loss. Penguins also have them in the flippers and nasal passages. Seabirds distill seawater using countercurrent exchange in a so-called salt gland with a rete mirabile. The gland secretes ...
The second application example for the MCSGP prototype is the separation of three MAb variants using a preparative weak cation-exchange resin. Although the intermediately eluting MAb variant can only be obtained with 80% purity at recoveries close to zero in a batch chromatographic process, the MCSGP process can provide 90% purity at 93% yield.
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