Search results
Results from the WOW.Com Content Network
Four stereoisomers of 8-OH-HHC arise from C8-hydroxylation of hexahydrocannabinol. There are four possible 8-OH-HHC metabolites arising from naturally derived HHCs: cis-and trans-8-OH-9α-HHC & cis-and trans-8-OH-9β-HHC. All four have been prepared synthetically to probe stereochemical effects on cannabinoid biological activity. [5]
The same study found D9-THC to have an EC50 of 3.9nM ± 0.5nM at CB1 and 2.5nM ± 0.7nM at CB2. The EC50 shows 9R-HHC has a lower selectivity for CB2 (0.55x) compared to THC (1.5x). HHC has been typically described as weaker than Delta-9-THC in psychoactive effects. HHC produces 11-Hydroxyhexahydrocannabinol and 8-Hydroxyhexahydrocannabinol ...
[1] [2] [3] In a pathway that parallels the metabolism of the THC family of cannabinoids, following ingestion HHC undergoes hepatic metabolism by cytochrome p450 (predominantly the CYP3A4 isozyme, with some contribution from CYP2C9 and CYP2C19 ) to a multitude of oxygenated derivatives, including 8-OH-HHC and 11-OH-HHC.
Certiorari was granted in the case on May 2, 2022. Amici briefs on in support of HHC were submitted by the National Conference of State Legislatures and the American Healthcare Association. Amici in support of Talevski were submitted by Public Citizen, the Constitutional Accountability Center, and the AARP. The case was argued on November 8, 2022.
9-Hydroxyhexahydrocannabinol (9-OH-HHC) is a semi-synthetic derivative of tetrahydrocannabinol. It is formed as an impurity in the synthesis of Delta-8-THC , [ 1 ] and retains activity in animal studies though with only around 1/10 the potency of Δ 9 -THC, with the 9α- and 9β- enantiomers having around the same potency.
For example, Δ 9-THC has an EC 50 of 250 nM at CB 1 and 1157 nM at CB 2, whereas PB-22 has an EC 50 of 5.1 nM at CB 1 and 37 nM at CB 2. [8] Adverse effects observed due to synthetic cannabinoid use include acute kidney injury , cardiac toxicity , seizure , stroke , tremor , hypokalemia , and rhabdomyolysis .
The data suggest that for every incident of distribution, possession, or use of alcohol referred to local law enforcement from schools without regular contact with SROs, 1.76 are referred in schools with regular contact with SROs, with p < 0.001. This is after controlling for state statutes that require school officials to refer students to law ...
In an in vitro analysis by the University of Rhode Island on cannabinoids it was found that 11-OH-Δ 9-THC had the 3rd highest 3C-like protease inhibitor activity against COVID-19 out of all the cannabinoids tested within that study but not as high as the antiviral drug GC376 (56% for 11-OH-Δ 9-THC vs. 100% for GC376).