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  2. Muscarinic acetylcholine receptor - Wikipedia

    en.wikipedia.org/wiki/Muscarinic_acetylcholine...

    Muscarinic acetylcholine receptors (mAChRs) are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons [1] and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibers .

  3. Muscarinic agonist - Wikipedia

    en.wikipedia.org/wiki/Muscarinic_agonist

    A muscarinic acetylcholine receptor agonist, also simply known as a muscarinic agonist or as a muscarinic agent, is an agent that activates the activity of the muscarinic acetylcholine receptor. [1] The muscarinic receptor has different subtypes, labelled M1-M5, allowing for further differentiation.

  4. Muscarinic acetylcholine receptor M3 - Wikipedia

    en.wikipedia.org/wiki/Muscarinic_acetylcholine...

    The muscarinic M 3 receptor regulates insulin secretion from the pancreas [7] and are an important target for understanding the mechanisms of type 2 diabetes mellitus.. Some antipsychotic drugs that are prescribed to treat schizophrenia and bipolar disorder (such as olanzapine and clozapine) have a high risk of diabetes side-effects.

  5. Acetylcholine receptor - Wikipedia

    en.wikipedia.org/wiki/Acetylcholine_receptor

    Molecular biology has shown that the nicotinic and muscarinic receptors belong to distinct protein superfamilies.Nicotinic receptors are of two types: Nm and Nn. Nm [1] is located in the neuromuscular junction which causes the contraction of skeletal muscles by way of end-plate potential (EPPs).

  6. List of investigational antipsychotics - Wikipedia

    en.wikipedia.org/wiki/List_of_investigational...

    Emraclidine (CVL-231) – M 4 muscarinic acetylcholine receptor positive allosteric modulator. [10] ML-007 – M 1 and M 4 muscarinic acetylcholine receptor agonist. [11] NBI-1117568 (HTL 0016878) – M 4 muscarinic acetylcholine receptor agonist. [12] NS-136 – M 4 muscarinic acetylcholine receptor positive allosteric modulator [13]

  7. FDA approves new pain medication as an alternative to opioids ...

    www.aol.com/news/fda-approves-pain-medication...

    The drug, suzetrigine, received the FDA's official stamp of approval Thursday to be sold as a 50-milligram prescription pill taken every 12 hours, according to a press release.

  8. Muscarinic antagonist - Wikipedia

    en.wikipedia.org/wiki/Muscarinic_antagonist

    A muscarinic acetylcholine receptor antagonist, also simply known as a muscarinic antagonist or as an antimuscarinic agent, is a type of anticholinergic drug that blocks the activity of the muscarinic acetylcholine receptors (mAChRs). The muscarinic receptors are proteins involved in the transmission of signals through certain parts of the ...

  9. Muscarinic acetylcholine receptor M4 - Wikipedia

    en.wikipedia.org/wiki/Muscarinic_acetylcholine...

    12672 Ensembl ENSG00000180720 ENSMUSG00000040495 UniProt P08173 P32211 RefSeq (mRNA) NM_000741 NM_001366692 NM_007699 RefSeq (protein) NP_000732 NP_001353621 NP_031725 Location (UCSC) Chr 11: 46.38 – 46.39 Mb Chr 2: 91.76 – 91.76 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The muscarinic acetylcholine receptor M 4, also known as the cholinergic receptor, muscarinic 4 (CHRM4 ...