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The major objective of the trial was to compare the efficacy of low-dose helical computed tomography (CT screening) and standard chest X-ray as methods of lung cancer screening. [2] The primary study ended in 2010, and the initial findings were published in November 2010, with the main results published in 2011 in the New England Journal of ...
Rodents have been employed in biomedical experimentation from the 1650s. [1] Rodent studies up to the early 19th century were mainly physiological or toxicological.The first rodent behavioral study was carried out in 1822, a purely observational study [2], while quantitative rodent behavioral testing began in the late 19th century [1] [2].
The cages are constructed and designed in a specific way to ensure an absolute microparticle free inner environment. This generally includes a cage bottom, a cage top (with a food hopper and water bottle holder incorporated) and a filter lid. It is also designed to allow maximum comfort of the animal and to provide a secure, chew proof environment.
The Irwin screen was as of 2010 in the pharmaceutical industry almost exclusively used with lab mice, whereas the FOB, or some modification thereof, was used with lab rats and other nonrodent species, such as rabbits, dogs, guinea pigs and nonhuman primates.
The test may be useful as a sensitive indicator of trauma induced by brain injury to laboratory rats. [7] Alcohol markedly impairs mouse performance in the rotarod test. [8] Research using the rotarod test with various chemical agonists and antagonists may help scientists determine which components of neurons mediate the effects of chemicals. [9]
Laboratory rats or lab rats are strains of the rat subspecies Rattus norvegicus domestica (Domestic Norwegian rat) which are bred and kept for scientific research. While less commonly used for research than laboratory mice , rats have served as an important animal model for research in psychology and biomedical science [ 1 ] , and "lab rat" is ...
While Calhoun was working at the National Institute of Mental Health (NIMH) in 1954, he began numerous experiments with rats and mice. During his first tests, he placed around 32 to 56 rats in a 10-by-14-foot (3.0 m × 4.3 m) cage in a barn in Montgomery County. He separated the space into four rooms.
Rat Park was a series of studies into drug addiction conducted in the late 1970s and published between 1978 and 1981 by Canadian psychologist Bruce K. Alexander and his colleagues at Simon Fraser University in British Columbia, Canada.