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Participants received capmatinib 400 mg orally twice daily until disease progression or unacceptable toxicity. [ 6 ] [ 4 ] The efficacy was based on results from 97 of the participants. [ 5 ] The trial was conducted at 92 sites in the United States, Austria, Belgium, France, Germany, Israel, Italy, Japan, Korea, Lebanon, Mexico, Netherlands ...
The 111-patient study tested two doses of setanaxib, 400 mg once daily and 400 mg twice daily, versus placebo. The primary endpoint was percentage change in serum gamma-glutamyl transferase (GGT) at 24 weeks; the study did not meet this endpoint.
In rats, this dose was 1000 mg/kg/day, which is approximately 24 times a human dose of 200 mg twice daily based on mg/m 2 /day. In rabbits, the highest dose tested was 90 mg/kg/day, which is approximately four times a human dose of 200 mg twice daily based on mg/m 2 /day. This dose produced severe maternal toxicity and resulted in fetal ...
Study 19 (NCT00753545) randomized 265 patients regardless of BRCA status (1:1) to receive olaparib capsules 400 mg orally twice daily or placebo. [27] Study 19 demonstrated a statistically significant improvement in investigator-assessed PFS in patients treated with olaparib vs. placebo with a HR of 0.35. [27]
Sonlicromanol was well tolerated in doses as high as 800 mg single dose and 400 mg twice daily. Both the Sonlicromanol- and placebo-treated groups reported headache as the most frequent adverse effect. Only if the plasma concentration gets higher than 500 ng/mL, an increased heart rate and blood pressure are observed.
Pfizer announced on Dec. 1 that it was discontinuing phase 3 clinical trials of the twice-daily version due to high rates of adverse side effects. While these were mostly mild, a large percentage ...
EMA401 dose of up to 400 mg was tested in healthy male adults without any major adverse effects.. [16] EMA401 has been administered orally at a standardized dose of 100 mg twice daily. EMA401 reaches a maximum plasma concentration of 1000 ug/L one-hour after administration of 100 mg of EMA401 in both men and women, as observed in a phase II ...
A new study has found that consuming 6 milligrams of the coffee compound cafestol twice daily for 12 ... (mg) of cafestol twice daily for 12 weeks may lead to slight weight and body fat loss, but ...