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Dental anesthesia (or dental anaesthesia) is the application of anesthesia to dentistry. ... Lidocaine's half-life in the body is about 1.5–2 hours. [2]
Articaine is a dental amide-type local anesthetic. It is the most widely used local anesthetic in a number of European countries [ 2 ] and is available in many countries. It is the only local anaesthetic to contain a thiophene ring , meaning it can be described as 'thiophenic'; this conveys lipid solubility.
Minimum alveolar concentration or MAC is the concentration, often expressed as a percentage by volume, of a vapour in the alveoli of the lungs that is needed to prevent movement (motor response) in 50% of subjects in response to surgical (pain) stimulus.
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life ( elimination half-life , pharmacological half-life ) is the time taken for concentration of a biological substance (such as a medication ) to decrease from its maximum concentration ( C max ) to half of C max in the blood plasma .
Dental anesthesiology is the specialty of dentistry that deals with the advanced use of general anesthesia, sedation and pain management to facilitate dental procedures.. In the United States, a dentist anesthesiologist is a dentist who has successfully completed an accredited postdoctoral anesthesiology residency program of three or more years duration, in accordance with the Commission on ...
MEGX has a longer half-life than lidocaine, but also is a less potent sodium channel blocker. [50] The volume of distribution is 1.1 L/kg to 2.1 L/kg, but congestive heart failure can decrease it. About 60% to 80% circulates bound to the protein alpha 1 acid glycoprotein. The oral bioavailability is 35% and the topical bioavailability is 3%.
There is an important relationship between clearance, elimination half-life and distribution volume. The elimination rate constant of a drug K e l {\displaystyle K_{el}} is equivalent to total clearance divided by the distribution volume
Skin paleness – usually disappear in few minutes to half an hour. [6] Tissue necrosis – usually seen in the hard palate. Avoid too much pressure and limit amount of anaesthetic for palatal infiltrations. [7] Haematoma formation – is formed due to prickle of the blood vessels. It rarely results in serious complications.
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