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Tinea cruris is treated by applying antifungal medications of the allylamine or azole type to the groin region. Studies suggest that allylamines (naftifine and terbinafine) are a quicker but more expensive form of treatment compared to azoles ( clotrimazole , econazole , ketoconazole , oxiconazole , miconazole , sulconazole ). [ 6 ]
Individuals with tinea pedis are likely to have infection at multiple sites. [12] Infections can be spontaneously cured or controlled by topical antifungal treatment. Although T. rubrum tinea pedis in children is extremely rare, it has been reported in children as young as two years of age. [13]
They are usually used topically for the treatment of skin infections. [11] Naftifine Naftifine is used topically for the treatment of dermatophytosis, including tinea cruris (jock itch), tinea corporis (ringworm of the body), tinea pedis (athlete's foot) and tinea manuum (ringworm of the hand). It is available in creams or gels.
The side effects of oral treatment are significant and people without an infection should not take these drugs. [36] Azoles are the group of antifungals which act on the cell membrane of fungi. They inhibit the enzyme 14-alpha-sterol demethylase, a microsomal CYP, which is required for the biosynthesis of ergosterol for the cytoplasmic membrane.
Tinea corporis (also known as "ringworm", [2] tinea circinata, [11] and tinea glabrosa [2]) is a superficial fungal infection (dermatophytosis) of the arms and legs, especially on glabrous skin; however, it may occur on any part of the body, it present as annular, marginated plaque with thin scale and clear center.
Athlete's foot, known medically as tinea pedis, is a common skin infection of the feet caused by a fungus. [2] Signs and symptoms often include itching, scaling, cracking and redness. [ 3 ] In rare cases the skin may blister . [ 6 ]
Naftifine hydrochloride (brand names include Exoderil and Naftin) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (topical fungal infections). Naftifine was invented at the Sandoz Research Institute in Vienna, Austria. It was the first successful antifungal medication of the allylamine ...
Trichophyton rubrum and Trichophyton interdigitale cause athlete's foot (tinea pedis), toenail fungal infections (a.k.a. tinea unguium, a.k.a. onychomycosis), crotch itch (a.k.a. tinea cruris), and ringworm (a misnomer, as there is no worm involved; it is also known as tinea corporis).
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