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1,3-Bisphosphoglyceric acid (1,3-Bisphosphoglycerate or 1,3BPG) is a 3-carbon organic molecule present in most, if not all, living organisms.It primarily exists as a metabolic intermediate in both glycolysis during respiration and the Calvin cycle during photosynthesis. 1,3BPG is a transitional stage between glycerate 3-phosphate and glyceraldehyde 3-phosphate during the fixation/reduction of ...
Molecular structure diagrams used in drug-related pharmacology articles should be created using a molecule editor program, such as ChemDraw, ChemSketch, or ISIS/Draw (ChemDraw and Isis/draw are commercial software packages, ChemSketch is freeware.
If SVG files are required, it is recommended that structure diagrams be exported as enhanced metafiles (.emf) which can be read by Inkscape and other image editors. From the "Options" menu, choose "Set Structure Drawing Style" → ACS Style; Draw the structure or reaction diagram; Export the file as PNG or EMF for further processing (see below)
1,3-BPG is formed as an intermediate in glycolysis. BPGM then takes this and converts it to 2,3-BPG, which serves an important function in oxygen transport. 2,3-BPG binds with high affinity to Hemoglobin, causing a conformational change that results in the release of oxygen. Local tissues can then pick up the free oxygen.
2,3-BPG is formed from 1,3-BPG by the enzyme BPG mutase.It can then be broken down by 2,3-BPG phosphatase to form 3-phosphoglycerate.Its synthesis and breakdown are, therefore, a way around a step of glycolysis, with the net expense of one ATP per molecule of 2,3-BPG generated as the high-energy carboxylic acid-phosphate mixed anhydride bond is cleaved by 2,3-BPG phosphatase.
Phosphoglycerate kinase (EC 2.7.2.3) (PGK 1) is an enzyme that catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP producing 3-phosphoglycerate (3-PG) and ATP : 1,3-bisphosphoglycerate + ADP ⇌ glycerate 3-phosphate + ATP. Like all kinases it is a transferase. PGK is a major enzyme used in ...
2,3-Bisphosphoglycerate (2,3-BPG) Bisphosphoglycerate mutase; Bisphosphoglycerate phosphatase This page was last edited on 12 May 2022 ...
The systematic name of this enzyme class is 2,3-bisphospho-D-glycerate 2-phosphohydrolase. Other names in common use include 2,3-diphosphoglycerate phosphatase , diphosphoglycerate phosphatase , 2,3-diphosphoglyceric acid phosphatase , 2,3-bisphosphoglycerate phosphatase , and glycerate-2,3-diphosphate phosphatase .