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In 1951, Pauling published the structure of the alpha helix, a fundamentally important structural component of proteins. In early 1953, Pauling published a triple helix model of DNA, which subsequently turned out to be incorrect. [3] Both Crick, and particularly Watson, thought that they were racing against Pauling to discover the structure of DNA.
The Linus Pauling Institute still exists, but moved in 1996 from Palo Alto, California, to Corvallis, Oregon, where it is part of the Linus Pauling Science Center at Oregon State University. [ 181 ] [ 182 ] [ 183 ] The Valley Library Special Collections at Oregon State University contain the Ava Helen and Linus Pauling Papers, including ...
Narrated by Jeff Goldblum, it features Watson, Wilkins, Gosling and Peter Pauling (son of Linus Pauling). [27] A play entitled Photograph 51 by Anna Ziegler focuses on the role of X-ray crystallographer Rosalind Franklin in the discovery of the structure of DNA. [28] [29] This play won the third STAGE International Script Competition in 2008. [30]
Far from making his jaw drop and his pulse race, the revelation that DNA was a simple a twisting helix would therefore have been a disappointment but it is intriguing to speculate on how differently history might have unfolded had Astbury shown Beighton's image to his friend and colleague the eminent US chemist and Nobel Laureate, Linus Pauling ...
Pauling had deduced this structure from X-ray patterns and from attempts to physically model the structures. (Pauling was also later to suggest an incorrect three chain helical DNA structure based on Astbury's data.) Even in the initial diffraction data from DNA by Maurice Wilkins, it was evident that the structure involved helices.
Franklin told Crick and Watson that the backbones had to be on the outside. Before then, Linus Pauling, and Watson and Crick, had erroneous models with the chains inside and the bases pointing outwards. Franklin's identification of the space group for DNA crystals revealed to Crick that the two DNA strands were antiparallel. [207]
Robert Brainard Corey (August 19, 1897 – April 23, 1971) was an American biochemist, mostly known for his role in discovery of the α-helix and the β-sheet with Linus Pauling. Also working with Pauling was Herman Branson. Their discoveries were remarkably correct, with even the bond lengths being accurate until about 40 years later.
Some of these structures were proposed during the 1950s before the structure of the double helix was solved, most famously by Linus Pauling. Non-helical or "side-by-side" models of DNA were proposed in the 1970s to address what appeared at the time to be problems with the topology of circular DNA chromosomes during replication (subsequently ...