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Pauling then proposed that deoxyribonucleic acid (DNA) was a triple helix; [60] [61] his model contained several basic mistakes, including a proposal of neutral phosphate groups, an idea that conflicted with the acidity of DNA.
Some of these structures were proposed during the 1950s before the structure of the double helix was solved, most famously by Linus Pauling. Non-helical or "side-by-side" models of DNA were proposed in the 1970s to address what appeared at the time to be problems with the topology of circular DNA chromosomes during replication (subsequently ...
In 1951, Pauling published the structure of the alpha helix, a fundamentally important structural component of proteins. In early 1953, Pauling published a triple helix model of DNA, which subsequently turned out to be incorrect. [3] Both Crick, and particularly Watson, thought that they were racing against Pauling to discover the structure of DNA.
Triple-stranded DNA (also known as H-DNA or Triplex-DNA) is a DNA structure in which three oligonucleotides wind around each other and form a triple helix. In triple-stranded DNA, the third strand binds to a B-form DNA (via Watson–Crick base-pairing ) double helix by forming Hoogsteen base pairs or reversed Hoogsteen hydrogen bonds.
In 1952, Corey and Pauling published a description of space-filling models of proteins and other biomolecules that they had been building at Caltech. [3] Their models represented atoms by faceted hardwood balls, painted in different bright colors to indicate the respective chemical elements. Their color schema included White for hydrogen; Black ...
The double-helix model of DNA structure was first published in the journal Nature by James Watson and Francis Crick in 1953, [6] (X,Y,Z coordinates in 1954 [7]) based on the work of Rosalind Franklin and her student Raymond Gosling, who took the crucial X-ray diffraction image of DNA labeled as "Photo 51", [8] [9] and Maurice Wilkins, Alexander Stokes, and Herbert Wilson, [10] and base-pairing ...
It covered the discovery of DNA in 1953. [1] Maurice Wilkins and his involvement with the Manhattan Project, speaking in his university office in London; Linus Pauling's son Peter, of Caltech, now lived in Wales; Linus Pauling approached the discovery of the structure of DNA in a much more methodical rigid manner, perhaps in a plodding way, and Pauling was never one to take the same un-thought ...
This image, along with the knowledge that Linus Pauling had proposed an incorrect structure of DNA, "mobilised" [9] Watson and Crick to restart model building. With additional information from research reports of Wilkins and Franklin, obtained via Max Perutz , Watson and Crick correctly described the double-helix structure of DNA in 1953.