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Fenfluramine is indicated for the treatment of seizures associated with Dravet syndrome and Lennox–Gastaut syndrome in people age two and older. [3] [7] [4]Dravet syndrome is a life-threatening, rare and chronic form of epilepsy. [7]
Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4]
An instant rebate, or sometimes instant savings, is a marketing strategy or gimmick in which a product is either advertised at a specific price, or at a discounted price, where the discount is applied at the time of purchase.
Second, our brand point of sale discount programs generate clear and affordable cash prices for brand medications. We ended the year with 78 signed brands, nearly three times the number we began ...
Coupons can be used to research the price sensitivity of different groups of buyers (by sending out coupons with different dollar values to different groups). Time, location and sizes (e.g. five pound vs. 20 pound bag) [12] affect prices; coupons are part of the marketing mix. [13] So is knowing about the customer. [14] [12]
A horizontal indirect spend GPO succeeds in reducing procurement costs by aggregating the demand for non-strategic, or indirect cost supplies and services used by a broad horizontal market spectrum of member client organizations by consolidating purchasing power and establishing contracts to achieve preferred pricing, terms, and service standards.
No improvement in clinical benefit; risk for death; veno-occlusive disease. [2] Pemoline (Cylert) 1997 Canada, UK Withdrawn from US in 2005 due to hepatotoxicity. [41] [3] Pentobarbital: 1980 Norway Risk of fatal overdose. [3] Pentylenetetrazol: 1982 US Withdrawn for inability to produce effective convulsive therapy, and for causing seizures.
Phenylpropanolamine was previously available in the United States over-the-counter and in certain combination drug forms by prescription. [24] [25] One such example of the latter was a combination of phenylpropanolamine and chlorpheniramine, which dually contained decongestant and antihistamine effects, marketed by Tutag as 'Vernate'.
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