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  2. Tramadol - Wikipedia

    en.wikipedia.org/wiki/Tramadol

    Long-term use of high doses of tramadol causes physical dependence and withdrawal syndrome. [39] These include both symptoms typical of opioid withdrawal and those associated with serotonin–norepinephrine reuptake inhibitor (SNRI) withdrawal; symptoms include numbness, tingling, paresthesia, and tinnitus. [40]

  3. List of side effects of tramadol - Wikipedia

    en.wikipedia.org/wiki/List_of_side_effects_of...

    Bradycardia; Hypertension (high blood pressure); Allergic reactions (e.g. dyspnoea (shortness of breath), bronchospasm, wheezing, angioneurotic oedema) Anaphylaxis; Changes in appetite

  4. Dirty drug - Wikipedia

    en.wikipedia.org/wiki/Dirty_drug

    In pharmacology, a dirty drug is an informal term for drugs that may bind to many different molecular targets or receptors in the body, and so tend to have a wide range of effects and possibly adverse drug reactions.

  5. Opioid-induced hyperalgesia - Wikipedia

    en.wikipedia.org/wiki/Opioid-induced_hyperalgesia

    Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long-term use of high dosages of opioids [1] such as morphine, [2] oxycodone, [3] and methadone. [4] [5] OIH is not necessarily confined to the original affected site. [6]

  6. 21 foods that lower blood pressure — and which foods to avoid

    www.aol.com/17-foods-lower-blood-pressure...

    In addition to food sources of omega-3 fatty acids, omega-3 supplements may also play a role in helping to reduce blood pressure, especially fish oil supplements with EPA and DHA.

  7. Tapentadol - Wikipedia

    en.wikipedia.org/wiki/Tapentadol

    Tramadol has several enantiomers, and each forms metabolites after processing in the liver. These tramadol variants have varying activities at the μ-opioid receptor, the norepinephrine transporter, and the serotonin transporter, and differing half-lives, with the metabolites having the best activity. Using tramadol as a starting point, the ...

  8. Weight-loss drug Wegovy only works when you take it. Is it ...

    www.aol.com/news/weight-loss-drug-wegovy-only...

    Doctors explain why the drug semaglutide needs to be taken for the long term and if it's safe. ... the least amount of side effects. ... a natural hormone the body releases when a person eats food ...

  9. Opioid overdose - Wikipedia

    en.wikipedia.org/wiki/Opioid_overdose

    Higher doses of prescription opioids, as well as long-acting formulations, are associated with an increased risk of overdose. [24] In those on long-term opioid treatment for chronic pain, daily morphine equivalents greater than 200 mg were associated with death from opioid related causes (including overdose) in 3.8% of men and 2.2% of women. [24]

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