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AdoHcyase is encoded by the AHCY gene in humans, [6] [7] which is believed to have a prognostic role in neuroblastoma. [8] AdoHcyase is significantly associated with adenosine deaminase deficiency, which classically manifests in severe combine immunodeficiency (SCID).
The GNMT gene provides instructions for making the enzyme glycine N-methyltransferase. This enzyme starts the next step in the process, converting S-adenosylmethionine to a compound called S-adenosyl homocysteine. The AHCY gene provides instructions for producing the enzyme S-adenosylhomocysteine hydrolase.
The SHH gene is a member of the hedgehog gene family with five variations of DNA sequence alterations or splice variants. [37] SHH is located on chromosome seven and initiates the production of Sonic Hedgehog protein. [37] This protein sends short- and long-range signals to embryonic tissues to regulate development. [38]
NB: Each list page contains 5000 human protein-coding genes, sorted alphanumerically by the HGNC-approved gene symbol. Follow the Python code link for information about updates to the list of genes on these pages.
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