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Levothyroxine. Levothyroxine, also known as L-thyroxine, is a synthetic form of the thyroid hormone thyroxine (T 4 ). [ 5][ 8] It is used to treat thyroid hormone deficiency (hypothyroidism), including a severe form known as myxedema coma. [ 5] It may also be used to treat and prevent certain types of thyroid tumors. [ 5]
The Wolff–Chaikoff effect is known as an autoregulatory phenomenon that inhibits organification in the thyroid gland, the formation of thyroid hormones inside the thyroid follicle, and the release of thyroid hormones into the bloodstream. [ 6] This becomes evident secondary to elevated levels of circulating iodide.
Levothyroxine is the chemical name of the manufactured version of T 4, which is metabolised more slowly than T 3 and hence usually only needs once-daily administration. Natural desiccated thyroid hormones are derived from pig thyroid glands, and are a "natural" hypothyroid treatment containing 20% T 3 and traces of T 2 , T 1 and calcitonin .
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CAS Number. 8001-24-9. Desiccated thyroid extract ( DTE ), is thyroid gland that has been dried and powdered for medical use. [ 1] It is used to treat hypothyroidism ., [ 1] but less preferred than levothyroxine. [ 1] It is taken by mouth. [ 1] Maximal effects may take up to three weeks to occur.
Levothyroxine should be used to keep TSH levels within the normal range for that trimester. The first trimester normal range is below 2.5 mIU/L and the second and third trimesters normal range is below 3.0 mIU/L. [ 15 ] [ 44 ] Treatment should be guided by total (rather than free) thyroxine or by the free T 4 index .