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Acanthosis nigricans. Acanthosis nigricans is a medical sign characterised by brown-to-black, poorly defined, velvety hyperpigmentation of the skin. [1] It is usually found in body folds, [2] such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead and other areas. [1]
The HAIR-AN syndrome is a rare subtype of polycystic ovary syndrome (PCOS) characterized by hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). The symptoms of the HAIR-AN syndrome are largely due to severe insulin resistance, which can be secondary to blocking antibodies against the insulin receptor or genetically absent/reduced insulin receptor number/function.
People with Crouzonodermoskeletal syndrome have acanthosis nigricans, a skin condition characterized by thick, dark, velvety skin in body folds and creases, including the neck and underarms. In addition, subtle changes may be seen in the bones of the spine ( vertebrae ). Noncancerous growths called cementomas may develop in the jaw during young ...
Rabson–Mendenhall syndrome is a rare autosomal recessive disorder characterized by severe insulin resistance. The disorder is caused by mutations in the insulin receptor gene. Symptoms include growth abnormalities of the head, face and nails, along with the development of acanthosis nigricans. Treatment involves controlling blood glucose ...
Severe achondroplasia with developmental delay and acanthosis nigricans is inheried in an autosomal dominant manner. [2] Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN) is a very rare genetic disorder. This disorder is one that affects bone growth and is characterized by skeletal, brain, and skin abnormalities.
Donohue syndrome (also known as leprechaunism) is an extremely rare and severe genetic disorder. Leprechaunism derives its name from the hallmark elvish features (small stature, bulging eyes, thick lips, and upturned nostrils) exhibited by the affected individuals. The disease is caused by a mutation in the INSR gene, which contains the genetic ...
Helene Ollendorff Curth (28 February 1899 – 17 June 1982) was a German-American dermatologist, known for her studies on acanthosis nigricans (AN) and introducing Curth's criteria, a set of characteristics for associating skin signs as markers for internal cancers. She is named in two rare inherited skin diseases, the Buschke–Ollendorff ...
“Physical examinations [of children] might reveal slight liver enlargement,” said Aslam, “and some children and young adults could have patchy, dark skin discoloration (acanthosis nigricans ...