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This process of absorption works to reduce the risk of DNA damage and the formation of pyrimidine dimers. UVA light makes up 95% of the UV light that reaches earth, whereas UVB light makes up only about 5%. UVB light is the form of UV light that is responsible for tanning and burning. Sunscreens work to protect from both UVA and UVB rays.
These enzymes require visible light (from the violet/blue end of the spectrum) both for their own activation [1] and for the actual DNA repair. [2] The DNA repair mechanism involving photolyases is called photoreactivation. They mainly convert pyrimidine dimers into a normal pair of pyrimidine bases.
Light therapy is preferred over antidepressants in the treatment of SAD because it is a relatively safe and easy therapy. [20] Two methods of light therapy, bright light and dawn simulation, have similar success rates in the treatment of SAD. [21] It is possible that response to light therapy for SAD could be season dependent. [22]
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For non-seasonal depression, adding light therapy to the standard antidepressant treatment was not effective. [167] A meta-analysis of light therapy for non-seasonal depression conducted by Cochrane Collaboration, studied a different set of trials, where light was used mostly in combination with antidepressants or wake therapy.
Light therapy has been shown in studies to have mixed results; in some studies, 20% to 50% of those diagnosed with SAD did not gain adequate relief from the use of light therapy. [22] Individuals may also explore alternative treatments if they are unable to commit to the time required and the recurrence of the treatment that is necessary. [23]
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