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Anti-smooth muscle antibodies are antibodies (immunoglobulins) formed against smooth muscle. These antibodies are typically associated with autoimmune hepatitis. [1] [2] These antibodies can be directed against actin, troponin, and tropomyosin. [3]
A number of specific antibodies found in the blood (antinuclear antibody (ANA), anti-smooth muscle antibody (SMA), anti-liver kidney microsomal antibodies (LKM-1, LKM-2, LKM-3), anti soluble liver antigen (SLA), liver–pancreas antigen (LP), and anti-mitochondrial antibody (AMA)) are of use, as is finding an increased immunoglobulin G level.
Antinuclear antibodies and anti-smooth muscle antibody are found in 20–50% of PSC patients, and likewise are not specific for the disease, but may identify a subgroup of PSC patients who also have autoimmune hepatitis (i.e. PSC-AIH overlap syndrome). [4]
Anti-mitochondrial antibodies (AMA) are autoantibodies, consisting of immunoglobulins formed against mitochondria, [1] primarily the mitochondria in cells of the liver.. The presence of AMA in the blood or serum of a person may be indicative of the presence of, or the potential to develop, the autoimmune disease primary biliary cholangitis (PBC; previously known as primary biliary cirrhosis).
Anti-neutrophil cytoplasmic antibody: c-ANCA: proteins in neutrophil cytoplasm: granulomatosis with polyangiitis: p-ANCA: neutrophil perinuclear: microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, systemic vasculitides (non-specific) Rheumatoid factor: IgG: rheumatoid arthritis: Anti-smooth muscle antibody: smooth muscle ...
Anti-neutrophil cytoplasmic antibody; Anti-nRNP; Anti-Scl-70 antibodies; Anti-smooth muscle antibody; ... Liver kidney microsomal type 1 antibody; M.
Liver kidney microsomal type 1 antibody (anti-LKM1) is an autoantibody associated with autoimmune hepatitis (AIH). [1] Specifically, its presence in AIH defines type 2 AIH, [ 2 ] [ 3 ] although it has been proposed that anti-liver cytosol type 1 autoantibody without detectable anti-LKM1 can be seen in type 2 AIH. [ 4 ]
Auto-antibodies found in patients with autoimmune hepatitis include the sensitive but less specific anti-nuclear antibody (ANA), smooth muscle ... Liver biopsy is the ...
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