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Paroxetine was the first antidepressant approved in the United States for the treatment of panic disorder. [27] [page needed] Several studies have concluded that paroxetine is superior to placebo in the treatment of panic disorder. [25] [28] Paroxetine has demonstrated efficacy for the treatment of social anxiety disorder in adults and children.
Drug companies are prohibited from promoting drugs for unapproved uses, but doctors are permitted to prescribe drugs for what is known as off-label use. In the UK 32,000 prescriptions of paroxetine were written for children and adolescents in 1999, [ 49 ] and in the US that figure rose to 2.1 million in 2002, earning GSK $55 million.
Billions of dollars are spent annually on researching and developing drugs, but the truth of the matter, according to Medscape, is that just one out of every 5,000 to 10,000 compounds studied in ...
The top 16 best selling pharmaceuticals of 2017/18. [2] Rank Drug ... For the fourth quarter of 2013, the largest selling drugs were: [5] Rank Brand Name(s) Generic Name
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification. Chemical/generic names are listed first, with brand names in parentheses.
Paroxetine was the first drug to be approved for social anxiety disorder and it is considered effective for this disorder; sertraline and fluvoxamine were later approved for it as well. Escitalopram and citalopram are used off-label with acceptable efficacy, while fluoxetine is not considered to be effective for this disorder. [ 22 ]
As demonstrated in table 2, paroxetine also inhibits the NOSs enzyme which could be the reason for its sexual dysfunction adverse effect, especially in men. [18] Paroxetine shows the highest affinity for muscarinic receptors of all the SSRIs which results in weak anticholinergic activity and therefore undesirable adverse effects. [44]
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