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General paresis, also known as general paralysis of the insane (GPI), paralytic dementia, or syphilitic paresis is a severe neuropsychiatric disorder, classified as an organic mental disorder, and is caused by late-stage syphilis and the chronic meningoencephalitis and cerebral atrophy that are associated with this late stage of the disease when left untreated.
Neurosyphilis is the infection of the central nervous system by Treponema pallidum, the bacterium that causes the sexually transmitted infection syphilis.In the era of modern antibiotics, the majority of neurosyphilis cases have been reported in HIV-infected patients.
Syphilis has been known as "the great imitator", because it may cause symptoms similar to many other diseases. [2] [3] Syphilis is most commonly spread through sexual activity. [2] It may also be transmitted from mother to baby during pregnancy or at birth, resulting in congenital syphilis.
The trend puts “real lives at stake,” with cases having risen 80% since 2018, experts say.
What you need to know about STDs. Syphilis, gonorrhea, chlamydia and herpes. Debunking myths about sexually transmitted infections.
Stage 4: Tertiary Stage - Most people with untreated syphilis do not develop tertiary syphilis, but when it does happen, many different organ systems are affected. These include the heart, blood ...
Cause [ edit ] Tabes dorsalis is caused by demyelination by advanced syphilis infection ( tertiary syphilis ) when the primary infection by the causative spirochete bacterium , Treponema pallidum , is left untreated for an extended period of time (past the point of blood infection by the organism). [ 3 ]
Meningeal syphilis (as known as syphilitic aseptic meningitis or meningeal neurosyphilis) is a chronic form of syphilis infection that affects the central nervous system. Treponema pallidum , a spirochate bacterium, is the main cause of syphilis, which spreads drastically throughout the body and can infect all its systems if not treated ...