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Staphylococcus epidermidis is a Gram-positive bacterium, and one of over 40 species belonging to the genus Staphylococcus. [1] It is part of the normal human microbiota , typically the skin microbiota , and less commonly the mucosal microbiota and also found in marine sponges.
PSMs were first described as a pro-inflammatory molecule. [2] This role has been repeatedly demonstrated to be true. PSMs are able to induce the production of a variety of cytokines as well as induce neutrophils to migrate to sites of infection. [3] PSMε in S. epidermidis is known to influence the production of IL-8. [3]
Examples include clumping factor A (ClfA), fibronectin binding protein A (FnbpA) from Staphylococcus aureus, SdrG from Staphylococcus epidermidis, M protein from Streptococcus pyogenes, and protein G in other Streptococcus species. All of these MSCRAMMs bind to fibrinogen, but also other targets for MSCRAMMs are known, such as fibronectin.
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Bovine submaxillary mucin (BSM) coatings are a surface treatment provided to biomaterials intended to reduce the growth of disadvantageous bacteria and fungi such as S. epidermidis, E. coli, and Candida albicans. [2] BSM is a substance extracted from the fresh salivary glands of cows.
S. epidermidis, a coagulase-negative staphylococcus species, is a commensal of the skin, but can cause severe infections in immune-suppressed patients and those with central venous catheters. S. saprophyticus , another coagulase -negative species that is part of the normal vaginal flora , is predominantly implicated in uncomplicated lower ...
Staphylococcus epidermidis under a scanning electron microscope. The skin microbiota is vital as a line of defense against infection, a physical barrier between the environment and the inside of the host. Commensal microbes that live on the skin, such as Staphylococcus epidermidis, produce antimicrobial peptides (AMPs) that aid the host immune ...
Potential probiotic treatment includes the use of Staphylococcus epidermidis to inhibit C. acnes growth. S. epidermidis produces succinic acid which has been shown to inhibit C. acnes growth. [42] Lactobacillus plantarum has also been shown to act as an anti-inflammatory and improve antimicrobial properties of the skin when applied topically ...