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People in sepsis may have micronutrient deficiencies, including low levels of vitamin C. [13] Reviews mention that an intake of 3.0 g/day via intravenous administration may needed to maintain normal plasma concentrations. [14] [15] Sepsis mortality is reduced with administration of intravenous vitamin C. [16]
Vitamin C supplements among other dietary supplements at a US drug store. Vitamin C has a definitive role in treating scurvy, which is a disease caused by vitamin C deficiency. Beyond that, a role for vitamin C as prevention or treatment for various diseases is disputed, with reviews often reporting conflicting results.
Vitamin C megadosage is a term describing the consumption or injection of vitamin C (ascorbic acid) in doses well beyond the current United States Recommended Dietary Allowance of 90 milligrams per day, and often well beyond the tolerable upper intake level of 2,000 milligrams per day. [1]
Since the first claims of medical breakthroughs with vitamin C by Pauling and others, findings on the health effects of vitamin C have been controversial and contradictory. [34] [35] Pauling's claims have been criticised as overbroad. [36] Later research branched out into nutrients besides niacin and vitamin C, including essential fatty acids. [37]
For example, the Food and Drug Administration recommends that adults on a 2,000 calorie diet get between 60 and 90 milligrams of vitamin C per day. [18] This is the middle of the bell curve. The upper limit is 2,000 milligrams per day for adults, which is considered potentially dangerous. [19]
Dehydroascorbic acid (DHA) is an oxidized form of ascorbic acid (vitamin C). It is actively imported into the endoplasmic reticulum of cells via glucose transporters. [1] It is trapped therein by reduction back to ascorbic acid by glutathione and other thiols. [2]
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Overweight, obesity and diet-related noncommunicable diseases (such as heart disease, stroke, diabetes and some cancers). [ 84 ] In developed countries, the diseases of malnutrition are most often associated with nutritional imbalances or excessive consumption; there are more people in the world who are malnourished due to excessive consumption.
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