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  2. DNA laddering - Wikipedia

    en.wikipedia.org/wiki/DNA_laddering

    DNA laddering (left) visualised in an agarose gel by ethidium bromide staining. A 1 kb marker (middle) and control DNA (right) are included.. DNA laddering is a feature that can be observed when DNA fragments, resulting from Apoptosis DNA fragmentation are visualized after separation by gel electrophoresis the first described in 1980 by Andrew Wyllie at the University Edinburgh medical school ...

  3. Apoptotic DNA fragmentation - Wikipedia

    en.wikipedia.org/wiki/Apoptotic_DNA_fragmentation

    The apoptotic DNA fragmentation is being used as a marker of apoptosis and for identification of apoptotic cells either via the DNA laddering assay, [2] the TUNEL assay, [3] [4] or the by detection of cells with fractional DNA content ("sub G 1 cells") on DNA content frequency histograms e.g. as in the Nicoletti assay.

  4. Molecular-weight size marker - Wikipedia

    en.wikipedia.org/wiki/Molecular-weight_size_marker

    A molecular-weight size marker, also referred to as a protein ladder, DNA ladder, or RNA ladder, is a set of standards that are used to identify the approximate size of a molecule run on a gel during electrophoresis, using the principle that molecular weight is inversely proportional to migration rate through a gel matrix.

  5. DNA Specimen Provenance Assignment - Wikipedia

    en.wikipedia.org/wiki/DNA_Specimen_Provenance...

    DNA Specimen Provenance Assignment (DSPA) also known as DNA Specimen Provenance Assay, is a molecular diagnostic test used to definitively assign biopsy specimen identity and establish specimen purity during the diagnostic testing cycle for cancer and other histopathological conditions.

  6. Agarose gel electrophoresis - Wikipedia

    en.wikipedia.org/wiki/Agarose_gel_electrophoresis

    The DNA size marker is a commercial 1 kbp ladder. The position of the wells and direction of DNA migration is noted. Agarose gel electrophoresis is a method of gel electrophoresis used in biochemistry , molecular biology , genetics , and clinical chemistry to separate a mixed population of macromolecules such as DNA or proteins in a matrix of ...

  7. 5 cancer types where screenings save the most lives - AOL

    www.aol.com/5-cancer-types-where-screenings...

    Over a 45-years span — between 1975 and 2020 — improvements in cancer screenings and prevention strategies have reduced deaths from five common cancers more than any advances in treatments ...

  8. Restriction digest - Wikipedia

    en.wikipedia.org/wiki/Restriction_digest

    Restriction digest is most commonly used as part of the process of the molecular cloning of DNA fragment into a vector (such as a cloning vector or an expression vector).The vector typically contains a multiple cloning site where many restriction site may be found, and a foreign piece of DNA may be inserted into the vector by first cutting the restriction sites in the vector as well the DNA ...

  9. Molecular diagnostics - Wikipedia

    en.wikipedia.org/wiki/Molecular_diagnostics

    Currently, a lot of PCR and hybridization assays have been approved by FDA as in vitro diagnostics. [47] NGS assays, however, are still at an early stage in clinical diagnostics. [48] To do the molecular diagnostic test for cancer, one of the significant issue is the DNA sequence variation detection.

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