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[6] [7] [8] [3] Tedizolid is a second-generation oxazolidinone derivative that is 4-to-16-fold more potent against staphylococci and enterococci compared to linezolid. [9] The recommended dosage for treatment is 200 mg once daily for a total duration of six days, either orally (with or without food) or through an intravenous injection (if ...
Additionally, Tedizolid was shown to have fewer treatment-related side effects than linezolid and significantly fewer GI side effects. [6] Trius was planning the second Phase 2 trial and expects to report results around the end of Q1 2013 and planned to submit an NDA to the FDA for the drug in the second half of 2013. [7]
Antibiotics that usually have activity against vancomycin-resistant Enterococcus (VRE): . Linezolid and Tedizolid; Streptogramins such as quinupristin-dalfopristin; Advanced generation tetracyclines: Tigecycline, Omadacycline, Eravacycline
Linezolid is a member of the oxazolidinone class of medications. [10] Linezolid was discovered in the mid-1990s, and was approved for commercial use in 2000. [16] [17] It is on the World Health Organization's List of Essential Medicines. [18] The World Health Organization classifies linezolid as critically important for human medicine. [19]
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Linezolid (Zyvox), which is available for intravenous administration and also has the advantage of having excellent oral bioavailability. Posizolid, which appears to have excellent, targeted bactericidal activity against all common gram-positive bacteria, regardless of resistance to other classes of antibiotics. [10] Chemical structure of tedizolid
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It differs from linezolid by replacement of the morpholine oxygen with a sulfur atom. Like linezolid, sutezolid is a bacterial protein synthesis inhibitor . In preclinical studies, sutezolid demonstrated superior antituberculosis activity compared to linezolid.