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Immunohistochemistry for CK7 of a metastatic undifferentiated carcinoma to a lymph node. Because the keratin-7 antigen is found in both healthy and neoplastic cells, antibodies to CK7 can be used in immunohistochemistry to distinguish ovarian and transitional cell carcinomas (staining positive) from colonic and prostate cancers (negative), respectively.
Keratin 20, often abbreviated CK20, is a protein that in humans is encoded by the KRT20 gene. [5] [6] [7]Keratin 20 is a type I cytokeratin.It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa.
Primary EMPD tests positive for CK7 but negative for CK20, whereas secondary is positive for both. [15] Lack of positivity for hormone receptors and HER2 protein is overexpressed meaning that the cells are dividing rapidly and can be indicate an aggressive and more recurrent disease. [citation needed]
Adenosquamous carcinoma is a type of cancer that contains two types of cells: squamous cells (thin, flat cells that line certain organs) and gland-like cells. It has been associated with more aggressive characteristics when compared to adenocarcinoma in certain cancers. [1] [2] It is responsible for 1% to 4% of exocrine forms of pancreas cancer ...
Pseudomyxoma peritonei (PMP) is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that produce abundant mucin or gelatinous ascites. [1] The tumors cause fibrosis of tissues and impede digestion or organ function, and if left untreated, the tumors and mucin they produce will fill the abdominal cavity.
Papillary renal cell carcinoma (PRCC) is a malignant, heterogeneous tumor originating from renal tubular epithelial cells of the kidney, which comprises approximately 10-15% of all kidney neoplasms. [1] Based on its morphological features, PRCC can be classified into two main subtypes, which are type 1 and type 2 (eosinophilic). [2]
"Constant negative news promoting beliefs that the world is a dangerous place where people cannot be trusted can alter one’s perceptions of social dynamics and inspire political apathy.
Krukenberg tumors often come to the attention when they cause abdominal or pelvic pain, bloating, ascites, or pain during sexual intercourse.Krukenberg tumors can occasionally provoke a reaction of the ovarian stroma which leads to hormone production, that results in vaginal bleeding, a change in menstrual habits, or hirsutism, [3] or occasionally virilization [4] as a main symptom.