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Bisphenol A (BPA) is a chemical ... although it can interact with other receptor systems as an endocrine ... This displays the structure–activity relationship which ...
Bisphenols A (BPA), F (BPF) and S (BPS) have been shown to be endocrine disruptors, potentially relating to adverse health effects. [3] [6] Due to its high production volumes, BPA has been characterised as a "pseudo-persistent" chemical, [7] leading to its spreading and potential accumulation in a variety of environmental matrices, even though it has a fairly short half-life.
Bisphenol A is an endocrine disruptor that can mimic estrogen and has been shown to cause negative health effects in animal studies. Bisphenol A closely mimics the structure and function of the hormone estradiol by binding to and activating the same estrogen receptor as the natural hormone.
Addition of further Bisphenol A and a catalyst and heat can produce Bisphenol A glycidyl ether epoxy resins of higher molecular weight that are solid. [8] Structure of bisphenol-A diglycidyl ether epoxy resin: n denotes the number of polymerized subunits and is typically in the range from 0 to 25
There is evidence that bisphenol A functions as a xenoestrogen by binding strongly to ERR-γ. [8] BPA as well as its nitrated and chlorinated metabolites seems to binds strongly to ERR-γ (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER)., [8] [10] BPA binding to ERR-γ preserves its basal constitutive activity. [8]
Phthalates are known as “endocrine disruptors” because they interfere with the endocrine system, which regulates hormones. The chemicals have been linked to reproductive health issues, low IQ ...
4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) is a metabolite of bisphenol A (BPA). [1] MBP has potent estrogenic activity in vitro and in vivo , up to thousandfold stronger than BPA. [ 2 ] It may also play a role in neuronal cell apoptosis [ 3 ] and may increase risk for several forms of cancer.
2. Plastic Bottles Can Leach Microplastics. Roughly 10% to 78% of bottled water samples contain contaminants, including microplastics. These are often hormone (endocrine) disruptors, and they're ...