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2. Stem cell transplantation for articular cartilage repair

   en.wikipedia.org/wiki/Stem_cell_transplantation...

   Stem cells, as a concept, originated as a theory in the 19th century to potentially allow certain tissues to self-renew. There are five types of stem cells, and MSC's are multi-potent, meaning they are cells that have the ability to develop into more than one type of specialized cell. Mesenchymal stem cells were originally discovered and ...

3. Knee cartilage replacement therapy - Wikipedia

   en.wikipedia.org/wiki/Knee_cartilage_replacement...

   Because mesenchymal stem cells may regenerate cartilage, cartilage growth in human knees using autologous cultured mesenchymal stem cells is under research and preliminary clinical use, and appears to be safe as of 2016. [11] An advantage to this approach is that a person's own stem cells are used, avoiding tissue rejection by the immune system ...

4. Articular cartilage repair - Wikipedia

   en.wikipedia.org/wiki/Articular_cartilage_repair

   In particular, mesenchymal stem cells have been shown in animal models to regenerate cartilage. Recently, there has been a published case report of decrease in knee pain in a single individual using autologous mesenchymal stem cells. An advantage to this approach is that a person's own stem cells are used, avoiding transmission of genetic diseases.

5. Kevin R. Stone - Wikipedia

   en.wikipedia.org/wiki/Kevin_R._Stone

   The replacement of the meniscus permits the arthritic patient to have improved pain relief and knee joint function as well as delay or avoid the time for artificial joint replacement. In a 2 to 7 year follow-up study, 89.4% of meniscus transplantation patients were successful, having shown significant signs of improvement in pain, activity, and ...

6. Microfracture surgery - Wikipedia

   en.wikipedia.org/wiki/Microfracture_surgery

   The surgery is performed by arthroscopy, after the joint is cleaned of calcified cartilage. Through use of an awl, the surgeon creates tiny fractures in the subchondral bone plate. [10] Blood and bone marrow (which contains stem cells) seep out of the fractures, creating a blood clot that releases cartilage-building cells.

7. Gene therapy for osteoarthritis - Wikipedia

   en.wikipedia.org/wiki/Gene_therapy_for...

   Joint inflammation is also a key mechanism in OA, [9] and a number of pro-inflammatory cytokines, particularly IL-1, have been implicated in pathophysiology, [10] [11] human genetics, [12] and animal models of disease. [13] In addition, osteoarthritis has a number of heritable factors, and there may be additional genetic risk factors for the ...