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Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Doxylamine succinate is the active ingredient in many over-the-counter sleep aids branded under various names. Doxylamine succinate and pyridoxine (Vitamin B6) are the ingredients of Diclegis, approved by the FDA in April 2013 becoming the only drug approved for morning sickness [46] with a class A safety rating for pregnancy (no evidence of risk).
Limited evidence from published clinical trials suggests the use of medications to treat hyperemesis gravidarum. [47] While pyridoxine/doxylamine, a combination of vitamin B 6 and doxylamine, is effective in nausea and vomiting of pregnancy, [48] some have questioned its effectiveness in HG. [49]
Antihistamines (H 1 histamine receptor antagonists) are effective in many conditions, including motion sickness, morning sickness in pregnancy, and to combat opioid nausea. H1 receptors in central areas include area postrema and vomiting center in the vestibular nucleus.
“Keep them cool, dry, and out of the sun.” So, probably not in your medicine cabinet. “Your pantry beats a steamy bathroom every time,” she adds. The bottom line.
Although described as "morning sickness," pregnant women can experience this nausea any time of day or night. The exact cause of morning sickness remains unknown. Nausea and vomiting in pregnancy is typically mild and self-limited, resolving on its own by the 14th week of pregnancy. Other causes should also be ruled out when considering treatment.
Morning sickness affects about 70–80% of all pregnant women to some extent. [4] [5] About 60% of women experience vomiting. [2] Hyperemesis gravidarum occurs in about 1.6% of pregnancies. [1] Morning sickness can negatively affect quality of life, result in decreased ability to work while pregnant, and result in health-care expenses. [3]
Dose a Time to peak Half-life b Metabolism Anticholinergic Diphenhydramine: 50 mg 2–3 hours 2–9 hours CYP2D6, others Yes Doxylamine: 25 mg 2–3 hours 10–12 hours CYP2D6, others Yes Hydroxyzine: 25–100 mg 2 hours 20 hours ADH, CYP3A4, others No Doxepin: 3–6 mg 2–3 hours 17 hours c: CYP2D6, others No (at low doses) Mirtazapine: 7.5 ...
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