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Metadoxine is a selective antagonist of the serotonin receptor subtype 5-HT 2B and displays high affinity to the gamma-aminobutyric acid (GABA) transporter. In vitro enzymatic assay revealed that metadoxine reduced the activity of the GABA transaminase enzyme, responsible for the degradation of GABA. Electrophysiological studies also showed ...
ATC code A05 Bile and liver therapy is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Silibinin , also known as silybin (both from Silybum, the generic name of the plant from which it is extracted), is the major active constituent of silymarin, a standardized extract of the milk thistle, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silychristin, silidianin, and others.
It was provided in the form of 200 mg oral capsules and four capsules were taken daily. [ 1 ] L -Ornithine, as the combination drug L -ornithine L -aspartate (LOLA), has been used in the treatment of hepatic encephalopathy and cirrhosis and is likewise described as hepatoprotective.
Lysine, ornithine and citrulline all have an affinity for cyanophycin synthase (L-aspartate-adding) enzyme CphA. [4] Wiefel, Bröker and Steinbüchel conducted an experiment demonstrating that citrulline-rich cyanophycin can be produced through the introduction of a citrulline-producing strain. [ 5 ]
This activation facilitates the second step, in which the α-amino group of aspartate attacks the ureido group. Attack by aspartate is the rate-limiting step of the reaction. This step produces free AMP and L-argininosuccinate. [3] Thermodynamically, adenylation of the citrulline ureido group is more favorable than the analogous phosphorylation.
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