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NSAIDS (e.g.: aspirin, ibuprofen, diclofenac, naproxen) Other anticoagulants or antiplatelet drugs; Medications that may decrease antiplatelet drug effect: [3] Carbamazepine; Erythromycin; Fluconazole; Omeprazole; Use of NSAIDs as part of dental management of patients with vascular disease should be discouraged as NSAIDs have antiplatelet effect.
These NSAIDs, while reducing inflammation, also inhibit platelet aggregation and increase the risk of gastrointestinal ulcers and bleeds. [11] COX-2 selective inhibitors have fewer gastrointestinal side effects, but promote thrombosis , and some of these agents substantially increase the risk of heart attack .
In whole, the NSAIDs prevent the prostaglandins from ever being synthesized, reducing or eliminating the inflammation and resulting pain. [citation needed] Some common examples of NSAIDs are aspirin, ibuprofen, and naproxen. The newer specific COX-inhibitors are not classified together with the traditional NSAIDs, even though they presumably ...
Platelets are small blood components that form a plug in the blood vessel wall that stops bleeding. Platelets also produce a variety of substances that stimulate the production of a blood clot. One of the most common causes of increased bleeding risk is exposure to nonsteroidal anti-inflammatory drugs (NSAIDs). The prototype for these drugs is ...
Prostaglandin inhibitors are drugs that inhibit the synthesis of prostaglandin in human body. [1] There are various types of prostaglandins responsible for different physiological reactions such as maintaining the blood flow in stomach and kidney, regulating the contraction of involuntary muscles and blood vessels, and act as a mediator of inflammation and pain.
As with other NSAIDs, potential side effects include gastrointestinal bleeding. [10] Long-term use has been associated with kidney failure, and rarely liver failure, and it can exacerbate the condition of patients with heart failure. [8] At low doses, it does not appear to increase the risk of heart attack; however, at higher doses it may. [10]
For pain or fever, effects typically begin within 30 minutes. [10] Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. [10] One common adverse effect is an upset stomach. [10] More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. [10]
This effect is mediated by the irreversible blockage of COX-1 in platelets, since mature platelets don't express COX-2. [ 14 ] This antiplatelet property makes aspirin useful for reducing the incidence of heart attacks; [ 13 ] heart attacks are primarily caused by blood clots, and their reduction with the introduction of small amounts of ...
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