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Coca-Cola used coca leaf extract in its products from 1885 until about 1903, when it began using decocainized leaf extract. [9] [10] [11] Extraction of cocaine from coca requires several solvents and a chemical process known as an acid–base extraction, which can fairly easily extract the alkaloids from the plant.
Trituration of the free base from cocaine hydrochloride (or "cooking") is done by dissolving the cocaine hydrochloride in water over constant heat, while simultaneously adding a base (such as baking soda) to form the free base cocaine. The free base of cocaine forms a solid "rock", pieces of which can be smoked directly (crack cocaine). [4]
The highest prevalence of cocaine use was in Australia and New Zealand (2.1%), followed by North America (2.1%), Western and Central Europe (1.4%), and South and Central America (1.0%). [36] Since 1961, the Single Convention on Narcotic Drugs has required countries to make recreational use of cocaine a crime. [37]
Drug precursors, also referred to as precursor chemicals or simply precursors, are substances used to manufacture illicit drugs. Most precursors also have legitimate commercial uses and are legally used in a wide variety of industrial processes and consumer products, such as medicines, flavourings, and fragrances.
In South America, coca paste, also known as cocaine base and, therefore, often confused with cocaine sulfate in North America, is relatively inexpensive and is widely used by low-income populations. The coca paste is smoked in tobacco or cannabis cigarettes and use has become widespread in several Latin American countries.
In a statement responding to questions from The Associated Press, the agency cited U.S. government figures showing that as coca cultivation in Bolivia doubled from 2006 to 2021, illicit cocaine ...
The hepatic enzyme carboxylesterase is an important part of cocaine's metabolism because it acts as a catalyst for the hydrolysis of cocaine in the liver, which produces these inactive metabolites. If ethanol is present during the metabolism of cocaine, a portion of the cocaine undergoes transesterification with ethanol, rather than undergoing ...
In 2005, scientists found surprisingly large quantities of benzoylecgonine in Italy's Po River and used its concentration to estimate the number of cocaine users in the region. [4] In 2006, a similar study was performed in the Swiss ski town of Saint-Moritz using wastewater to estimate the daily cocaine consumption of the population. [ 5 ]